August 2, 2025

Supplementary Fig.S24 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients

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MAIN FINDING: Somatic mutation timing provides insights into the evolutionary trajectory of lung adenocarcinoma.
KEY EVIDENCE: Analysis of various mutational signatures shows distinct patterns in mutation periods.
APPROACH: The study examines proportions of non-clustered, Omikli, and other mutations during different time frames.
SIGNIFICANCE: Understanding these mutational patterns can inform targeted therapies for lung adenocarcinoma in Chinese populations.

Implication

Analysis reveals mutational signatures across periods in lung adenocarcinoma, suggesting evolutionary patterns in Chinese patients.

The proportion of different mutational signatures that underlie the non-clustered, Omikli, and other mutations over different mutation periods.

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Qin et al. (2025) studied this question.

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Analysis reveals mutational signatures across periods in lung adenocarcinoma, suggesting evolutionary patterns in Chinese patients.

The proportion of different mutational signatures that underlie the non-clustered, Omikli, and other mutations over different mutation periods.