August 2, 2025

Supplementary Fig.S23 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients

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MAIN FINDING: The study reveals significant insights into somatic mutation timing and its implications for lung adenocarcinoma.
KEY EVIDENCE: Specific mutational signatures associated with kataegis were noted across different mutation periods in patients.
APPROACH: This work utilized comprehensive characterization methods focused on somatic mutations in lung adenocarcinoma samples.
SIGNIFICANCE: Understanding the evolutionary trajectory of lung adenocarcinoma can inform targeted therapies for patients.

Implication

This analysis uncovers the evolutionary trajectory of lung adenocarcinoma in Chinese patients, highlighting various mutational signatures and periods.

Abstract

The proportion of different mutational signatures that underlie Kataegis over different mutation periods.

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Cite This Study

Qin et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d01a8 https://doi.org/10.1158/0008-5472.29760736

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Implication

This analysis uncovers the evolutionary trajectory of lung adenocarcinoma in Chinese patients, highlighting various mutational signatures and periods.

Abstract

The proportion of different mutational signatures that underlie Kataegis over different mutation periods.

Supplementary Fig.S23 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Fig.S23 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients

Key Points

Implication

Abstract

Discussion

Cite This Study

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