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September 5, 2025European journal of medical researchOpen Access

HIF-1α: a bridge connecting sepsis and acute respiratory distress syndrome

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Authors

SLShi-Yan LiuHRHang RuanSLShusheng Li

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Overview

Narrative review explores the role of HIF-1α in sepsis and ARDS, highlighting potential therapeutic targets.

Key Points

  • HIF-1α plays a crucial role in linking sepsis and acute respiratory distress syndrome, driving inflammation.
  • The review elucidates the mechanisms by which HIF-1α contributes to pulmonary capillary permeability and respiratory failure.
  • In-depth examination of the interplay between inflammatory cells and HIF-1α within the context of sepsis is provided.
  • Targeting HIF-1α may present novel therapeutic avenues for managing complications of sepsis and ARDS.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68bb46a86d6d5674bccfe345https://doi.org/10.1186/s40001-025-03107-z
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Unraveling the role of HIF-1α in sepsis: from pathophysiology to potential therapeutics—a narrative review2024 · 47 citations
  2. 2[Mechanism of Extracellular Histone-Induced Endothelial Dysfunction Leading to Sepsis-Induced Acute Respiratory Distress Syndrome].2024
  3. 3Dual Roles of Hypoxia-Inducible Factor 1 in Acute Lung Injury: Tissue-Specific Mechanisms and Therapeutic Modulation2025 · 8 citations
  4. 4Dysregulation of the angiopoietin–Tie-2 axis in sepsis and ARDS2013 · 102 citations
  5. 5HIF-1α Promotes Macrophage Extracellular Trap Formation and Exacerbates Acute Lung Injury in Neonatal Sepsis2026