Key result
The Tie2 receptor and its angiopoietin ligands form a signaling axis key to vascular dyshomeostasis in sepsis and ARDS, a complication associated with 40% mortality.
The angiopoietin-Tie-2 signaling axis plays a key role in vascular leak and inflammation during sepsis and ARDS, presenting potential diagnostic, prognostic, and therapeutic implications.
No takes yet. Share an insight, caveat, or question.
May inform diagnostic and therapeutic strategies in sepsis and ARDS; leaves open prospective validation before practice change.
Samir M. Parikh (2013) conducted a review in Sepsis and ARDS. Angiopoietin-Tie-2 axis was evaluated. The Tie2 receptor and its angiopoietin ligands form a signaling axis key to vascular dyshomeostasis in sepsis and ARDS, a complication associated with 40% mortality.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: