Key result
Perturbations to the angiopoietin/Tie2 axis cause endothelial cell activation and contribute to the pathogenesis of sepsis, highlighting its potential as a prognostic biomarker and therapeutic target.
The Ang/Tie2 pathway is a key mediator of endothelial dysfunction in sepsis and severe malaria, offering potential prognostic and therapeutic utility.
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Should not change sepsis practice; leaves open whether Ang/Tie2 targeting improves outcomes in trials.
Leligdowicz et al. (2018) conducted a review in Sepsis. Ang/Tie2 axis targeted therapies was evaluated. Perturbations to the angiopoietin/Tie2 axis cause endothelial cell activation and contribute to the pathogenesis of sepsis, highlighting its potential as a prognostic biomarker and therapeutic target.
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