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December 8, 2008Expert Opinion on Therapeutic Targets

The angiopoietin-Tie2 system as a therapeutic target in sepsis and acute lung injury

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Key result

Targeted angiopoietin-2 inhibition with RNA aptamers or blocking antibodies is a potential anti-inflammatory and anti-vascular hyperpermeability strategy in the treatment of sepsis and ALI/ARDS.

Why the study?

Does targeted angiopoietin-2 inhibition or angiopoietin-1 modulation improve outcomes in sepsis and acute lung injury/ARDS?

Population

Patients and experimental models with sepsis and acute lung injury/acute respiratory distress syndrome

Design

Review

Authors

MHM. van der HeijdenApple (Israel)GAGeerten P. van Nieuw AmerongenUniversity of TasmaniaSCSunita ChedamniUniversity Medical Center

Discussion

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Member takes

Implication

Angiopoietin-2 inhibition remains investigational in sepsis and ARDS; hypothesis-generating without prospective outcome data.

Structured PICO

Does targeted angiopoietin-2 inhibition or angiopoietin-1 modulation improve outcomes in sepsis and acute lung injury/ARDS?

P
Population
Patients and experimental models with sepsis and acute lung injury (ALI)/acute respiratory distress syndrome (ARDS)
I
Intervention
Targeted angiopoietin-2 inhibition (with RNA aptamers or blocking antibodies) or angiopoietin-1
O
Outcome
Inflammation, vascular hyperpermeability, apoptosis, organ functions, and vital outcomes

The angiopoietin-Tie2 system, specifically through angiopoietin-2 inhibition, represents a promising therapeutic target for reducing inflammation and vascular hyperpermeability in sepsis and ARDS.

Cite This Study

Heijden et al. (2008) conducted a review in Sepsis and acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). Targeted angiopoietin-2 inhibition was evaluated. Targeted angiopoietin-2 inhibition with RNA aptamers or blocking antibodies is a potential anti-inflammatory and anti-vascular hyperpermeability strategy in the treatment of sepsis and ALI/ARDS.

synapsesocial.com/papers/6a71aac7439bab0cabc3a496https://doi.org/10.1517/14728220802626256
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Also Consider

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  1. 1ADMISSION ANGIOPOIETIN LEVELS IN CHILDREN WITH SEPTIC SHOCK2007 · 127 citations
  2. 2Opposing effect of angiopoietin‐1 on VEGF‐mediated disruption of endothelial cell–cell interactions requires activation of PKCβ2003 · 57 citations
  3. 3Transcriptional Profiling of Lipopolysaccharide-Induced Acute Lung Injury2004 · 182 citations
  4. 4Angiopoietin‐1 inhibits endothelial permeability, neutrophil adherence and IL‐8 production2003 · 154 citations
  5. 5Cell-based Angiopoietin-1 Gene Therapy for Acute Lung Injury2007 · 155 citations