April 24, 2006Journal of the American Society of Nephrology

Leaking Capillaries and White Lung in Sepsis—Is Angiopoietin 2 the Culprit?

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Population

22 patients with sepsis and 29 control patients in the general medical service, alongside in vitro human…

Design

Editorial

Authors

PSParikh S.M.Sachtleben Bergbau (Germany)TMTadanori MammotoMedical College of Wisconsin ASAylit SchultzBeth Israel Deaconess Medical Center

Discussion

Member takes

Implication

This editorial highlights translational evidence suggesting angiopoietin-2 plays a causal role in sepsis-induced pulmonary vascular leak, identifying it as a potential therapeutic target.

Structured PICO

Population

22 patients with sepsis and 29 control patients in the general medical service, alongside in vitro human microvascular endothelial cells and in vivo animal models

Comparator

Nonseptic controls and septic patients without multiorgan dysfunction

Outcome

Angiopoietin-2 concentrations and correlation with indicators of poor oxygenation (PaO2/FIO2)surrogate

This editorial highlights translational evidence suggesting angiopoietin-2 plays a causal role in sepsis-induced pulmonary vascular leak, identifying it as a potential therapeutic target.

Limitations

small sample size
requires further study to determine if additional upstream actions on larger vessels contribute
controlled clinical trials are required

Cite This Study

S.M. et al. (2006) studied this question.

synapsesocial.com/papers/6a6ffca475498292b7095e5a https://doi.org/10.1681/asn.2006030259

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Implication

This editorial highlights translational evidence suggesting angiopoietin-2 plays a causal role in sepsis-induced pulmonary vascular leak, identifying it as a potential therapeutic target.