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Pro-Apoptosis Effects of Yangzheng-Xiaoji Capsules in Hepatocellular Carcinoma: Activation of the p53-Induced Apoptotic Pathway and Inhibition of the PI3K/Akt Pathway

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Observational analysis finds improved apoptosis in hepatocellular carcinoma, highlighting p53 activation and PI3K inhibition.

YXC significantly promoted apoptosis in HCC cells by activating the p53-induced apoptotic pathway.
HPLC-Q-TOF-MS/MS identified 58 components in YXC, revealing its complex composition and potential anti-tumor mechanisms.
The study employed an MHCC97H mouse model to confirm that YXC inhibits the PI3K/Akt pathway effectively.
Results indicate YXC improves weight, dietary status, and survival rates in HCC mice, supporting its safety and therapeutic potential.

Zhou et al. (2025) studied this question.

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