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September 5, 2025Physiological ResearchOpen Access

Association of High-Sensitivity Cardiac Troponin I, Platelet Counts, and Total Bilirubin/Albumin Ratio with the Severity of Neonatal Hyperbilirubinemia

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Authors

FLFengmin LuGCGuohua ChenJYJinqing Yuan

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Overview

Observational analysis found higher hs-cTnI and B/A ratios in severe neonatal hyperbilirubinemia, suggesting significant associations.

Key Points

  • Neonates with severe hyperbilirubinemia showed significantly higher hs-cTnI concentrations compared to mild cases.
  • Median hs-cTnI levels were 64.1 ng/mL in severe cases, compared to 41.9 ng/mL in mild cases, indicating the severity of NHB.
  • Assessment was conducted on 82 neonates to evaluate hs-cTnI, platelet counts, and B/A ratios in correlation with NHB severity.
  • The findings suggest that hs-cTnI could potentially serve as a biomarker for evaluating the severity of neonatal hyperbilirubinemia.

Cite This Study

Lu et al. (2025) studied this question.

synapsesocial.com/papers/68bb49d26d6d5674bccffe49https://doi.org/10.33549/physiolres.935562
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cord-Blood High-Sensitivity Troponin-I Reference Interval and Association with Early Neonatal Outcomes2021 · 12 citations
  2. 2Associations of High-Sensitive Cardiac Troponin T in Healthy Newborns and Prolonged Second Stage of Labor, Neonatal and Maternal Factors: A Prospective Study2023 · 1 citations
  3. 3Cord blood troponin I levels: biomarker evidence of fetal cardiac injury in intrahepatic cholestasis of pregnancy2024 · 1 citations
  4. 4The influencing factors of amplitude-integrated electroencephalography and bilirubin-induced neurological dysfunction scores in neonates with hyperbilirubinemia: a cross-sectional study2026
  5. 5Correlation of troponin I with perinatal and neonatal outcomes in neonates with respiratory distress2009 · 5 citations