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September 5, 2025Italian Journal of MedicineOpen Access

Assessing tumor necrosis factor-α (-238 G/A and -308 G/A) genetic polymorphisms in sepsis susceptibility among cystic fibrosis patients

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Authors

QMQahtan A. MahdiNahrain University JHJabbar S. HassanNahrain University AHAbdulrhman M. Hassan Hadi

Discussion

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Implication

This investigation demonstrates higher sepsis risk linked to TNF-α (-238 G/A and -308 G/A) polymorphisms in cystic fibrosis patients, suggesting genetic susceptibility.

Key Points

Septic cystic fibrosis patients exhibited a higher frequency of TNF-α polymorphisms compared to non-septic patients.
In the study, 38.33% of septic patients had the heterozygous -238 G/A genotype, versus 21.66% in non-septic patients.
Altered alleles (-238 A and -308 A) were significantly more common in sepsis patients, indicating a genetic predisposition.
The findings highlight potential genetic markers for increased sepsis susceptibility in individuals with cystic fibrosis.

Cite This Study

Mahdi et al. (2025) studied this question.

synapsesocial.com/papers/68bb4d2d6d6d5674bcd01526 https://doi.org/10.4081/itjm.2025.2021

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Implication

This investigation demonstrates higher sepsis risk linked to TNF-α (-238 G/A and -308 G/A) polymorphisms in cystic fibrosis patients, suggesting genetic susceptibility.