What question did this study set out to answer?

The research aims to explore the association between TNF and LTA gene polymorphisms and tuberculosis risk in cystic fibrosis patients.

March 14, 2026European Respiratory Journal

Genetic polymorphisms in TNF genes and tuberculosis in cystic fibrosis patients

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Authors

GSGalina ShmarinaResearch Centre for Medical Genetics APAlexander PukhalskyResearch Centre for Medical Genetics NKNikolai KapranovResearch Centre for Medical Genetics

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Implication

Genetic analysis shows the role of TNF and LTA genes in tuberculosis risk among cystic fibrosis patients, implying genetic factors in disease vulnerability.

Key Points

The research aims to explore the association between TNF and LTA gene polymorphisms and tuberculosis risk in cystic fibrosis patients.
Investigated single nucleotide polymorphisms in the TNF and LTA genes using TaqMan allelic discrimination assay.
Enrolled 190 cystic fibrosis patients for genetic and clinical data analysis.
Compared the distribution of TNF and LTA allelic variants between cystic fibrosis patients and healthy subjects.
No significant difference in TNF and LTA allelic variants between cystic fibrosis patients and healthy controls.
-308A allele carriers had a higher prevalence of asthma (14.9%) compared to -308G carriers (5.3%).
Tuberculosis was documented in 7.9% of 252A/A carriers, while none of the 252G carriers had tuberculosis.
252A/A carriers showed significantly higher levels of plasma TGF-β1 compared to those with 252G allele.

Cite This Study

Shmarina et al. (2011) studied this question.

synapsesocial.com/papers/69b4fc44b39f7826a300cfd1 https://doi.org/10.1183/13993003/erj.38.suppl_55.p449

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Implication

Genetic analysis shows the role of TNF and LTA genes in tuberculosis risk among cystic fibrosis patients, implying genetic factors in disease vulnerability.

Genetic polymorphisms in TNF genes and tuberculosis in cystic fibrosis patients

Discussion

Member takes

Implication

Key Points

Cite This Study

Genetic polymorphisms in TNF genes and tuberculosis in cystic fibrosis patients

Discussion

Member takes

Implication

Key Points

Cite This Study

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