What question did this study set out to answer?

To determine whether the functional tumor necrosis factor-alpha (TNF-α)-308 promoter polymorphism influences genetic susceptibility to chronic obstructive pulmonary disease and lung cancer.

January 1, 2009Neoplasma

TNF-α-308 promotor polymorphism in patients with chronic obstructive pulmonary disease and lung cancer

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Authors

MSMarija StankovićUniversity of Belgrade ANAleksandra NestorovicPerutnina Ptuj (Slovenia)ATAndrija TomovićNovartis (Switzerland)

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Implication

Case-control study reveals reduced odds of chronic obstructive pulmonary disease in TNF-alpha-308 heterozygotes, suggesting a protective role against airway inflammation.

Key Points

To determine whether the functional tumor necrosis factor-alpha (TNF-α)-308 promoter polymorphism influences genetic susceptibility to chronic obstructive pulmonary disease and lung cancer.
Conducted a case-control study including 97 patients with chronic obstructive pulmonary disease (COPD), 70 patients with lung cancer (LC), and 102 healthy controls.
Genotyped the -308 functional promoter polymorphism of the TNF-alpha gene across all participants to compare allele and genotype frequencies.
Heterozygous carriers of the TNF-alpha-308 1/2 variant showed a significantly lower frequency in the COPD group compared to controls (p=0.043), corresponding to a 2.3-fold decreased risk of COPD (OR=0.44, 95% CI=0.20-0.97).
Patients with lung cancer exhibited a non-significant trend toward decreased distribution of TNF-alpha-308 1/2 heterozygotes compared to controls.

Cite This Study

Stanković et al. (2009) studied this question.

synapsesocial.com/papers/6ab094e33e9093c1477f71dc https://doi.org/10.4149/neo_2009_04_348

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Implication

Case-control study reveals reduced odds of chronic obstructive pulmonary disease in TNF-alpha-308 heterozygotes, suggesting a protective role against airway inflammation.

TNF-α-308 promotor polymorphism in patients with chronic obstructive pulmonary disease and lung cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

TNF-α-308 promotor polymorphism in patients with chronic obstructive pulmonary disease and lung cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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