Key result
The presence of the TNF alpha-308 polymorphism (TNF2 allele) was not associated with multiple sclerosis or other disease categories by matched-pair and group analyses.
Why the study?
Is the TNF2 allele associated with multiple sclerosis or other inflammatory/neurologic diseases compared to matched controls?
Population
110 MS patients from Olmsted County, MN, plus three other patient cohorts and matched controls from a Mayo…
Comparison
Presence of the TNF2 allele vs Matched controls
Design
Case-control
Authors
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No TNF2-MS association seen in case-control data; leaves open whether other TNF variants influence susceptibility and requires prospective validation.
Case-Control
Is the TNF2 allele associated with multiple sclerosis or other inflammatory/neurologic diseases compared to matched controls?
The TNF2 allele polymorphism is not associated with multiple sclerosis or other evaluated inflammatory and neurologic diseases.
Wingerchuk et al. (1997) conducted a case-control in Multiple sclerosis. TNF alpha-308 polymorphism (TNF2 allele) vs. Matched controls was evaluated on Association between the TNF2 allele and MS or other disease categories. The presence of the TNF alpha-308 polymorphism (TNF2 allele) was not associated with multiple sclerosis or other disease categories by matched-pair and group analyses.
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