August 1, 1997Neurology
Genetic variation in the tumor necrosis factor alpha gene and the outcome of multiple sclerosis
Why the study?
Is genetic variation in the TNF alpha gene associated with the severity and temporal course of multiple sclerosis?
Population
117 patients (78 with multiple sclerosis and 39 with schizophrenia) from Olmsted County, MN
Comparison
Variant alleles in the tumor necrosis factor… vs Wild-type alleles in the TNF alpha gene
Design
Cohort
Authors
Discussion
Loading...
Member takes
Implication
No link to common TNF variants seen in this cohort; leaves open rarer variants or other loci in MS course.
Structured PICO
Is genetic variation in the TNF alpha gene associated with the severity and temporal course of multiple sclerosis?
P
Population
117 patients (78 with multiple sclerosis and 39 with schizophrenia) from Olmsted County, MN
I
Intervention
Variant alleles in the tumor necrosis factor alpha (TNF alpha) gene
C
Comparator
Wild-type alleles in the TNF alpha gene
O
Outcome
Severity and temporal course of multiple sclerosis
Genetic variation in the TNF alpha gene does not appear to determine the clinical course or long-term outcome of multiple sclerosis.
Cite This Study
Weinshenker et al. (1997) studied this question.