Why the study?
Does the TNF-alpha G-308A polymorphism interact with smoking status to determine plasma levels of TNF-alpha and CRP in middle-aged adults?
Population
300 middle-aged male and female industrial employees (276 analyzed: 198 non-smokers and 78 regular smokers)
Comparison
TNF-alpha G-308A polymorphism and smoking status vs Non-smokers and different genotypes
Design
Cross-sectional
Authors
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Smoking raises CRP independently of TNF-alpha G-308A genotype; leaves open whether other variants mediate this link in middle-aged adults.
Does the TNF-alpha G-308A polymorphism interact with smoking status to determine plasma levels of TNF-alpha and CRP in middle-aged adults?
The TNF-alpha G-308A polymorphism does not mediate the effect of smoking on plasma CRP levels in middle-aged adults.
Gander et al. (2004) studied this question.
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