What question did this study set out to answer?

This study aims to investigate the association between the TNF-α rs1800629 polymorphism and COPD susceptibility in Vietnamese patients.

February 25, 2026The Application of Clinical GeneticsOpen Access

TNF-α rs1800629 Polymorphism in Vietnamese COPD Patients: Exploratory Evidence for Recessive Protective Association and Clinical Correlates

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Authors

HNHa NguyenPham Ngoc Thach University of Medicine DLDuong Hoang LeChulalongkorn University THTham HoPham Ngoc Thach University of Medicine

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Implication

A cross-sectional study examines the protective effects of TNF-α polymorphism on COPD in Vietnamese individuals, suggesting potential clinical implications.

Key Points

This study aims to investigate the association between the TNF-α rs1800629 polymorphism and COPD susceptibility in Vietnamese patients.
Cross-sectional study design involving 266 stable COPD patients and 320 healthy controls.
Genotyping performed using PCR-RFLP.
Clinical data collected from medical records and direct interrogation.
Statistical analyses included Chi-square/Fisher’s exact tests and multivariable logistic regression.
Sensitivity analysis conducted using a dataset of 2,660 observations.
A allele frequencies were 8.83% in COPD patients and 6.88% in controls with no significant difference (p > 0.05).
The AA genotype associated with approximately 96% reduced susceptibility to COPD (adjusted OR 0.039, p=0.022).
Independent predictors of symptoms included smoking, family history, and onset age ≥ 40 years.
Sensitivity analysis indicated protective effects of GA genotype on symptomatic outcomes.

Cite This Study

Nguyen et al. (2026) studied this question.

synapsesocial.com/papers/699e921bf5123be5ed05028e https://doi.org/10.2147/tacg.s586977

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Implication

A cross-sectional study examines the protective effects of TNF-α polymorphism on COPD in Vietnamese individuals, suggesting potential clinical implications.

TNF-α rs1800629 Polymorphism in Vietnamese COPD Patients: Exploratory Evidence for Recessive Protective Association and Clinical Correlates

Discussion

Member takes

Implication

Key Points

Cite This Study

TNF-α rs1800629 Polymorphism in Vietnamese COPD Patients: Exploratory Evidence for Recessive Protective Association and Clinical Correlates

Discussion

Member takes

Implication

Key Points

Cite This Study

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