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September 5, 2025Frontiers in Bioscience-LandmarkOpen Access

Potential Mechanism Connecting Preeclampsia to Autism Spectrum Disorder in Offspring: The Role of Microglial Abnormalities

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Authors

ZYZhu YingSWSiyi WeiXFXi Fu

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Overview

This review uncovers the connection between preeclampsia and autism spectrum disorder, highlighting microglial abnormalities.

Key Points

  • Preeclampsia significantly raises the risk of autism spectrum disorder in offspring, particularly due to microglial abnormalities.
  • Prenatal exposure to preeclampsia is linked to increased odds ratios of autism spectrum disorder in affected children.
  • Microglia play a critical role in neurodevelopment, influencing processes that may lead to autism spectrum disorder.
  • Understanding the relationship between preeclampsia and microglial abnormalities could lead to novel intervention strategies.

Cite This Study

Ying et al. (2025) studied this question.

synapsesocial.com/papers/68bb4de86d6d5674bcd01b41https://doi.org/10.31083/fbl36412
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Epigenetic Regulation of Imprinted Genes in the Neurodevelopment of Offspring Born to Women with Preeclampsia: A Review2026
  2. 2Neurodevelopmental Disruptions in Children of Preeclamptic Mothers: Pathophysiological Mechanisms and Consequences2024 · 5 citations
  3. 3Preeclampsia Onset, Days to Delivery, and Autism Spectrum Disorders in Offspring: Clinical Birth Cohort Study2024 · 10 citations
  4. 4Exploring Prenatal Factors Linked to Autism Spectrum Disorder2024 · 1 citations
  5. 5Tracing Autism’s Hidden Origins: Integrating EHR, AI Care Journeys, Exposomics, Mini-Brain assembloids, and RNA base modifications to Reveal Convergent Pathways2026