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April 18, 2026International Journal of Women s HealthOpen Access

Epigenetic Regulation of Imprinted Genes in the Neurodevelopment of Offspring Born to Women with Preeclampsia: A Review

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Authors

XQXingyi QiYZYing ZhangXLX Y Liu

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Overview

This review summarizes evidence linking preeclampsia to neurodevelopmental risks in offspring, suggesting epigenetic influences.

Key Points

  • The aim is to explore how preeclampsia may affect neurodevelopment in children through imprinted genes and epigenetic changes.
  • Conducted a literature search using databases such as PubMed and Scopus.
  • Analyzed studies published up to 2025.
  • Identified relevant articles using specific keywords related to preeclampsia and neurodevelopment.
  • Children born to women with preeclampsia have a higher risk of neurodevelopmental disorders.
  • Evidence points to epigenetic alterations, especially DNA methylation of imprinted genes, influencing brain development.
  • Findings show a potential link between placental function and neurodevelopment, although they remain mostly associative.

Cite This Study

Qi et al. (2026) studied this question.

synapsesocial.com/papers/69e320e740886becb6540178https://doi.org/10.2147/ijwh.s598686
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Neurodevelopmental Disruptions in Children of Preeclamptic Mothers: Pathophysiological Mechanisms and Consequences2024 · 5 citations
  2. 2Potential Mechanism Connecting Preeclampsia to Autism Spectrum Disorder in Offspring: The Role of Microglial Abnormalities2025
  3. 3Medical and social aspects of preeclampsia2024
  4. 4The Molecular Basis of the Augmented Cardiovascular Risk in Offspring of Mothers with Hypertensive Disorders of Pregnancy2024 · 16 citations
  5. 5DNA methylation and telomere length in 2–5 year olds with intrauterine preeclampsia exposure: a P4 sub-study2025 · 1 citations