Supplemental Figure S3 from Mitochondrial DNA Copy-Number Assessment Is a Potent Predictor for Prostate Cancer in White but Not Black Individuals

Melanie K. Flores; Jessica L. Janes; Mirajul Islam; Junxiang Wan; Jiali Liu; Romonia R. Reams; Li‐Ming Su; Kelvin Yen; Hemal H. Mehta; Allison Reagan; Lauren E. Howard; Emily Wiggins; Adriana C. Vidal; Stephen J. Freedland; Pinchas Cohen

doi:10.1158/1940-6207.30028915

September 2, 2025Open Access

Supplemental Figure S3 from Mitochondrial DNA Copy-Number Assessment Is a Potent Predictor for Prostate Cancer in White but Not Black Individuals

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Key Points

ROC curves indicate that mitochondrial DNA copy number is a potent predictor for prostate cancer in white individuals, but not in black individuals.
Analysis reveals significant differences in the predictive ability of plasma and white blood cell mtDNA in prostate cancer outcomes, emphasizing racial disparities.
Univariable models adjusting for PSA and mtDNA samples were used to derive the predictive strength for prostate cancer in the population studied.
Findings suggest that mitochondrial DNA assessment could improve screening strategies but highlights the need for tailored approaches based on ethnicity.

Implication

ROC curves show how mitochondrial DNA copy number predicts prostate cancer risk in white individuals, implying variations by race.

Abstract

Supplemental Figure S3 shows receiver operating characteristic (ROC) curves between univariable models adjusted for PSA (log-transformed) only, Plasma mtDNA only, and WBC mtDNA only, stratified by Black and White individuals.

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Cite This Study

Flores et al. (2025) studied this question.

synapsesocial.com/papers/68bb4e016d6d5674bcd02896 https://doi.org/10.1158/1940-6207.30028915

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Supplemental Figure S3 from Mitochondrial DNA Copy-Number Assessment Is a Potent Predictor for Prostate Cancer in White but Not Black Individuals

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplemental Figure S3 from Mitochondrial DNA Copy-Number Assessment Is a Potent Predictor for Prostate Cancer in White but Not Black Individuals

Key Points

Implication

Abstract

Discussion

Cite This Study

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