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September 2, 2025Open Access

Table S11 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models

Asael Roichman Gabriela Reyes‐Castellanos Ziqing Chen Zihong Chen Sarah J. Mitchell Michael R. MacArthur Akshada Sawant Llewelyn Levett Jesse R. Powers Victoria Burgo Maria Gomez-Jenkins Maria Ibrahim Xincheng Xu Beianka Tomlinson Xiang Hang Eric G. Pamer Yong Wei Yibin Kang Eileen White Joshua D. Rabinowitz

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Key Points

Dietary fiber shows varying effects on immune checkpoint blockade efficacy across different murine tumor models.
In significant comparisons of fecal metabolites from B16-OVA and YUMM1.1-9 models, no consistent benefits of dietary fiber were observed.
Assessment involved dietary variations with chow and specific high/low fiber diets in tumor models, leading to complex interactions in outcomes.
Findings suggest potential limitations in relying solely on dietary fiber to enhance immune responses in cancer therapy.

Implication

Analysis shows inconsistent effects of dietary fiber on immune checkpoint blockade in murine tumor models, highlighting complex interactions.

Abstract

Significant fecal metabolites from B16-OVA and YUMM1.1-9 tumor models in chow or HC_In8 vs. LC_In0 comparisons

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Cite This Study

Roichman et al. (2025) studied this question.

synapsesocial.com/papers/68bb4e016d6d5674bcd028e4 https://doi.org/10.1158/0008-5472.30028709

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Table S11 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models2025
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