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September 2, 2025Open Access

Table S9 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models

Asael Roichman Gabriela Reyes‐Castellanos Ziqing Chen Zihong Chen Sarah J. Mitchell Michael R. MacArthur Akshada Sawant Llewelyn Levett Jesse R. Powers Victoria Burgo Maria Gomez-Jenkins Maria Ibrahim Xincheng Xu Beianka Tomlinson Xiang Hang Eric G. Pamer Yong Wei Yibin Kang Eileen White Joshua D. Rabinowitz

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Key Points

Dietary fiber does not show a consistent effect on immune checkpoint blockade efficacy across various tumor models.
Fecal metabolite analysis reveals variability in response related to dietary fiber intake in murine tumors.
Observational analysis focuses on diverse murine tumor models to evaluate the influence of dietary fiber.
Findings highlight the need for further exploration of dietary interactions in cancer therapies.

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Implication

Analysis shows dietary fiber lacks consistent effects on immune checkpoint blockade efficacy in murine models, suggesting complex interactions.

Abstract

Fecal metabolite peak areas from the B16-OVA model

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Cite This Study

Roichman et al. (2025) studied this question.

synapsesocial.com/papers/68bb4e016d6d5674bcd02895 https://doi.org/10.1158/0008-5472.30028682

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Table S9 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models2025
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