Table S5 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models

Asael Roichman; Gabriela Reyes‐Castellanos; Ziqing Chen; Zihong Chen; Sarah J. Mitchell; Michael R. MacArthur; Akshada Sawant; Llewelyn Levett; Jesse R. Powers; Victoria Burgo; Maria Gomez-Jenkins; Maria Ibrahim; Xincheng Xu; Beianka Tomlinson; Xiang Hang; Eric G. Pamer; Yong Wei; Yibin Kang; Eileen White; Joshua D. Rabinowitz

doi:10.1158/0008-5472.30210032

Key Points

Dietary fiber appears to have an inconsistent effect on immune checkpoint blockade efficacy across different murine tumor models, highlighting variability.
In the B16-OVA model, serum metabolite peak areas were assessed, revealing no significant uniform impact of dietary fiber on treatment outcomes.
The analysis involved multiple murine tumor models, pointing to varying responses to dietary fiber's role in immune modulation.
This work suggests that dietary interventions may need to be individualized based on specific tumor characteristics and responses.

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Implication

Observational analysis reveals inconsistent effects of dietary fiber on immune checkpoint blockade efficacy across murine tumor models, suggesting a need for tailored dietary interventions.

Abstract

Serum metabolite peak areas from the B16-OVA model

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Roichman et al. (2025) studied this question.

synapsesocial.com/papers/68d7b3ddeebfec0fc52366da https://doi.org/10.1158/0008-5472.30210032

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Table S5 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Table S5 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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