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September 25, 2025Open Access

Table S8 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models

Asael Roichman Gabriela Reyes‐Castellanos Ziqing Chen Zihong Chen Sarah J. Mitchell Michael R. MacArthur Akshada Sawant Llewelyn Levett Jesse R. Powers Victoria Burgo Maria Gomez-Jenkins Maria Ibrahim Xincheng Xu Beianka Tomlinson Xiang Hang Eric G. Pamer Yong Wei Yibin Kang Eileen White Joshua D. Rabinowitz

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Key Points

Dietary fiber shows inconsistent impact on immune checkpoint blockade efficacy across murine tumor models, suggesting variability.
Significant serum metabolites identified from multiple tumor models highlight the complexity in dietary fiber's role in treatment response.
Evaluation of chow versus high and low carbohydrate diets reveals differing serum metabolite levels affecting immune response.
Findings suggest further investigation into dietary influences on immune responses in cancer treatments may be warranted.

Implication

Analysis reveals varying effects of dietary fiber on immune checkpoint blockade efficacy in tumor models, indicating potential inconsistencies.

Abstract

Significant serum metabolites from B16-OVA, YUMM1.1-9, and PyMT tumor models in chow or HC_In8 vs. LC_In0 comparisons

Discussion

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Cite This Study

Roichman et al. (2025) studied this question.

synapsesocial.com/papers/68d7b3ddeebfec0fc52366d8 https://doi.org/10.1158/0008-5472.30210023

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Table S8 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models2025
2Table S8 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models2025
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4Table S11 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models2025
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