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September 2, 2025Open Access

Supplementary Methods S1 from 6-[(1,4-Naphthoquinone-2-yl)methyl]thio–Glucose Conjugates, a Novel Targeted Approach for Advanced Prostate Cancer

Tobias Busenbender Dmitry N. Pelageev Jessica Hauschild Moritz Kaune Lukas Boeckelmann Christoph Krisp Mohamed E. Elsesy Alexandra Zielinski Thomas Mair Maria Riedner Ayham Moustafa Simone Venz Malte Kriegs Konstantin Hoffer Yuri E. Sabutski Ksenia L. Borisova Nadja Strewinsky Svetlana M. Kovach Ekaterina A. Khmelevskaya Hartmut Schlüter В. Ф. Ануфриев Derya Tilki Markus Graefen Wael Mansour Carsten Bokemeyer Sergey A. Dyshlovoy Gunhild von Amsberg

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Key Points

Novel glucose conjugates may enhance treatment strategies for advanced prostate cancer.
The synthesis involves 6-[(1,4-Naphthoquinone-2-yl)methyl]thio as a key component.
General synthetic procedures are detailed to support reproducibility.
This approach highlights a targeted method that could improve treatment efficacy.

Implication

Analysis of synthesis methods for glucose conjugates in advanced prostate cancer, implying potential therapeutic benefits.

Abstract

Supplementary Methods S1: General synthetic procedures and methods used for synthesis

Discussion

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Cite This Study

Busenbender et al. (2025) studied this question.

synapsesocial.com/papers/68bb4e016d6d5674bcd028f9 https://doi.org/10.1158/1535-7163.30028664

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S1 from 6-[(1,4-Naphthoquinone-2-yl)methyl]thio–Glucose Conjugates, a Novel Targeted Approach for Advanced Prostate Cancer2025
2Supplementary Methods S2 from 6-[(1,4-Naphthoquinone-2-yl)methyl]thio–Glucose Conjugates, a Novel Targeted Approach for Advanced Prostate Cancer2025
3Supplementary Figure S5 from 6-[(1,4-Naphthoquinone-2-yl)methyl]thio–Glucose Conjugates, a Novel Targeted Approach for Advanced Prostate Cancer2025
4Supplementary Figure S4 from 6-[(1,4-Naphthoquinone-2-yl)methyl]thio–Glucose Conjugates, a Novel Targeted Approach for Advanced Prostate Cancer2025
5Supplementary Figure S2 from 6-[(1,4-Naphthoquinone-2-yl)methyl]thio–Glucose Conjugates, a Novel Targeted Approach for Advanced Prostate Cancer2025

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Supplementary Figure S3 from 6-[(1,4-Naphthoquinone-2-yl)methyl]thio–Glucose Conjugates, a Novel Targeted Approach for Advanced Prostate Cancer2025
Data from 6-[(1,4-Naphthoquinone-2-yl)methyl]thio–Glucose Conjugates, a Novel Targeted Approach for Advanced Prostate Cancer2025
Supplementary Information (SI) from PSMA-Targeted Small Molecule–Drug Conjugates Based on a Postprolyl Peptidase–Cleavable Linker for the Treatment of Prostate Cancer2025