Supplementary Figure S2 from 6-[(1,4-Naphthoquinone-2-yl)methyl]thio–Glucose Conjugates, a Novel Targeted Approach for Advanced Prostate Cancer

Key Points

PeS-9 significantly alters mRNA expression of AR-FL and AR-V7 in prostate cancer cells.
Change in mRNA levels indicates potential effectiveness of glucose conjugates in targeting advanced prostate cancer.
Analysis conducted using 22Rv1 cancer cells highlights the role of PeS-9 in gene expression modulation.
These findings suggest further evaluation of glucose conjugates for targeted prostate cancer therapies.

Observational analysis reveals PeS-9 alters AR-FL and AR-V7 mRNA in 22Rv1 cells, suggesting a novel therapeutic avenue.

Supplementary Figure S2: Effect of PeS-9 on AR-FL and AR-V7 mRNA expression in 22Rv1 cells

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Busenbender et al. (2025) studied this question.

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