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September 5, 2025Open Access

Supplementary Figure S16 from RORγt Inhibition Reduces Protumor Inflammation and Decreases Tumor Growth in Experimental Models of Lung Cancer

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Experimental models reveal that inhibition of RORγt reduces inflammation and tumor growth in lung cancer, suggesting a potential therapeutic target.

Inhibition of RORγt reduces tumor growth in experimental lung cancer models, highlighting its potential as a treatment target.
Significant findings include decreased inflammation associated with RORγt inhibition, demonstrating its role in tumor dynamics.
Analysis included IL17A, IL17F, and IL22 promoter methylation and gene expression in lung adenocarcinoma (LUAD) patients.
This research supports the concept that targeting RORγt may improve outcomes in lung cancer treatment.

Yamada‐Hara et al. (2025) studied this question.

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Experimental models reveal that inhibition of RORγt reduces inflammation and tumor growth in lung cancer, suggesting a potential therapeutic target.