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September 5, 2025Open Access

Supplementary Figure S14 from RORγt Inhibition Reduces Protumor Inflammation and Decreases Tumor Growth in Experimental Models of Lung Cancer

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Experimental models reveal that RORγt inhibition decreases tumor growth and inflammation in lung cancer, suggesting a potential therapeutic target.

RORγt inhibition leads to reduced tumor growth in lung cancer models, and inflammation is also decreased.
In urethane-induced lung cancer models, deletion of the Rorc gene significantly impacts tumor progression.
Findings from experimental models illustrate the importance of RORγt in regulating inflammation linked to lung cancer.
These results highlight the therapeutic potential of targeting RORγt to manage lung cancer effectively.

Yamada‐Hara et al. (2025) studied this question.

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Experimental models reveal that RORγt inhibition decreases tumor growth and inflammation in lung cancer, suggesting a potential therapeutic target.