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September 5, 2025Open Access

Supplementary Figure S1 from RORγt Inhibition Reduces Protumor Inflammation and Decreases Tumor Growth in Experimental Models of Lung Cancer

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Authors

MYMiki Yamada‐HaraUniversity of California System LALauren AmayaUniversity of California System ZWZhihe WangUniversity of California System

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Implication

Experimental observation shows digoxin treatment decreases tumor growth in a KrasG12D-driven lung cancer model, suggesting inflammation's role in tumor progression.

Key Points

Digoxin treatment significantly reduces tumor growth in the KrasG12D lung cancer model, indicating its therapeutic potential.
Key cytokines involved in inflammation are altered by digoxin treatment, leading to decreased tumor progression.
The study utilized an experimental model of lung cancer to assess the impact of RORγt inhibition on tumor dynamics.
The findings highlight how targeting inflammation may provide a new approach for lung cancer therapies.

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Yamada‐Hara et al. (2025) studied this question.

synapsesocial.com/papers/68bb4e016d6d5674bcd0286f https://doi.org/10.1158/2326-6066.30028622

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Implication

Experimental observation shows digoxin treatment decreases tumor growth in a KrasG12D-driven lung cancer model, suggesting inflammation's role in tumor progression.

Supplementary Figure S1 from RORγt Inhibition Reduces Protumor Inflammation and Decreases Tumor Growth in Experimental Models of Lung Cancer

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Implication

Key Points

Cite This Study

Supplementary Figure S1 from RORγt Inhibition Reduces Protumor Inflammation and Decreases Tumor Growth in Experimental Models of Lung Cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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