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September 5, 2025Open Access

Supplementary Figure S13 from RORγt Inhibition Reduces Protumor Inflammation and Decreases Tumor Growth in Experimental Models of Lung Cancer

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Assessment reveals digoxin does not change M1, M2, or PD-1-expressing TAM levels in KrasG12D mice, indicating inflammation control is unaffected.

Digoxin treatment does not alter macrophage infiltration in lung cancer models, specifically M1, M2, and PD-1-expressing tumor-associated macrophages.
No changes were observed in the tumor-associated macrophage composition of KrasG12D mice after digoxin administration, implying stability in immune infiltration.
Observational analysis focused on macrophage populations—namely M1, M2, and PD-1-expressing TAMs—in experimental lung cancer models did not show significant shifts.
This finding suggests that digoxin does not influence tumor-associated macrophage dynamics, which could impact strategies to manage lung cancer inflammation.

Yamada‐Hara et al. (2025) studied this question.

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Assessment reveals digoxin does not change M1, M2, or PD-1-expressing TAM levels in KrasG12D mice, indicating inflammation control is unaffected.