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September 5, 2025Open Access

Supplementary Figure S11 from RORγt Inhibition Reduces Protumor Inflammation and Decreases Tumor Growth in Experimental Models of Lung Cancer

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Findings reveal digoxin treatment does not affect myeloid cell infiltration in KrasG12D mice, suggesting implications for lung cancer therapy.

Digoxin treatment does not affect myeloid cell infiltration into the lungs of KrasG12D mice, indicating specific immune interactions.
The study finds a reduction in protumor inflammation correlating with decreased tumor growth in preclinical lung cancer models.
Experimental models show that RORγt inhibition effectively reduces aspects of lung cancer progression and immune cell dynamics.
Findings suggest potential therapeutic pathways in targeting inflammation to manage lung cancer development.

Yamada‐Hara et al. (2025) studied this question.

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Findings reveal digoxin treatment does not affect myeloid cell infiltration in KrasG12D mice, suggesting implications for lung cancer therapy.