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September 5, 2025Open Access

Figure S1 from Tumor-Specific MHC-II Activates CD4⁺ and CD8⁺ T Cells in Head and Neck Squamous Cell Carcinoma to Boost Immunotherapy Efficacy

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Tumor-specific MHC-II significantly enhances activation of CD4 and CD8 T cells.
Immunotherapy efficacy improves with the activation of these T cells in patients with head and neck squamous cell carcinoma.
Flow chart clarifies patient cohorts involved in the study.
Findings imply MHC-II could be a target for enhancing immunotherapy responses.

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Observational analysis shows tumor-specific MHC-II boosts T cell activation in head and neck cancer, suggesting improved immunotherapy outcomes.

The flow chart of study cohorts.

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Zhang et al. (2025) studied this question.

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Observational analysis shows tumor-specific MHC-II boosts T cell activation in head and neck cancer, suggesting improved immunotherapy outcomes.

The flow chart of study cohorts.