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September 2, 2025Open Access

Table S4 from Tumor-Specific MHC-II Activates CD4⁺ and CD8⁺ T Cells in Head and Neck Squamous Cell Carcinoma to Boost Immunotherapy Efficacy

Yuying Zhang Jinbang Li Xiaoyu Guo Zhao Gao Ji‐An Pan Sheng Nong Jin-Lin Ma Gang Chen Jiali Zhang

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Key Points

Activation of CD4 and CD8 T cells enhances immunotherapy efficacy in head and neck squamous cell carcinoma.
Single-cell transcriptomic analysis provides detailed insights into the cellular clusters involved.
Tumor-specific MHC-II plays a crucial role in the immune response against cancer cells.
Findings suggest that targeting MHC-II could improve current immunotherapy strategies.

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Implication

Single-cell transcriptomics reveals how tumor-specific MHC-II activates CD4 and CD8 T cells, suggesting improved immunotherapy outcomes.

Abstract

Details of single-cell transcriptomics samples about all the cells clusters.

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Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68bb5f076d6d5674bcd02b4e https://doi.org/10.1158/0008-5472.30029692

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Table S5 from Tumor-Specific MHC-II Activates CD4<sup>+</sup> and CD8<sup>+</sup> T Cells in Head and Neck Squamous Cell Carcinoma to Boost Immunotherapy Efficacy2025
2Figure S2 from Tumor-Specific MHC-II Activates CD4<sup>+</sup> and CD8<sup>+</sup> T Cells in Head and Neck Squamous Cell Carcinoma to Boost Immunotherapy Efficacy2025
3Table S2 from Tumor-Specific MHC-II Activates CD4<sup>+</sup> and CD8<sup>+</sup> T Cells in Head and Neck Squamous Cell Carcinoma to Boost Immunotherapy Efficacy2025
4Table S1 from Tumor-Specific MHC-II Activates CD4<sup>+</sup> and CD8<sup>+</sup> T Cells in Head and Neck Squamous Cell Carcinoma to Boost Immunotherapy Efficacy2025
5Table S6 from Tumor-Specific MHC-II Activates CD4<sup>+</sup> and CD8<sup>+</sup> T Cells in Head and Neck Squamous Cell Carcinoma to Boost Immunotherapy Efficacy2025