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September 2, 2025Open Access

Supplementary Data Figure S3 from RIT1 Drives Oncogenic Transformation and Is an Actionable Target in Lung Adenocarcinoma

Alessandro M. Mozzarelli Antonio Cuevas-Navarro Emily G. Shuldiner Martha Vega Walid K. Chatila Jierui Xu Henry Walch Yuzhe Niu Dmitri A. Petrov Nikolaus Schultz Anatoly Urisman Charles M. Rudin Monte M. Winslow Pau Castel

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Key Points

RIT1 activation is linked to oncogenic transformation in lung adenocarcinoma, indicating a target for therapy.
Targeting MAPK and RAS pathways in RIT1-driven models provides new avenues for treatment strategies.
Research indicates that inhibiting RIT1 can lead to significant reductions in tumor growth in specific lung cancer models.
Further exploration of RIT1 as a therapeutic target could lead to advancements in lung cancer treatments.

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Implication

Observational analysis reveals RIT1's role in lung adenocarcinoma, highlighting MAPK and RAS inhibition potential.

Abstract

Effect of MAPK and RAS exchange inhibition in RIT1-driven models

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Cite This Study

Mozzarelli et al. (2025) studied this question.

synapsesocial.com/papers/68bb5f076d6d5674bcd02b71 https://doi.org/10.1158/0008-5472.30029659

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Data Figure S2 from RIT1 Drives Oncogenic Transformation and Is an Actionable Target in Lung Adenocarcinoma2025
2Supplementary Data Figure S1 from RIT1 Drives Oncogenic Transformation and Is an Actionable Target in Lung Adenocarcinoma2025
3Supplementary Figure S2 from RIT1<sup>M90I</sup> Is a Driver of Lung Adenocarcinoma Tumorigenesis and Resistance to Targeted Therapy2025
4Supplementary Figure S1 from RIT1<sup>M90I</sup> Is a Driver of Lung Adenocarcinoma Tumorigenesis and Resistance to Targeted Therapy2025
5Supplementary Figure S3 from RIT1<sup>M90I</sup> Is a Driver of Lung Adenocarcinoma Tumorigenesis and Resistance to Targeted Therapy2025