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September 2, 2025Open Access

Supplementary Data Figure S2 from RIT1 Drives Oncogenic Transformation and Is an Actionable Target in Lung Adenocarcinoma

Alessandro M. Mozzarelli Antonio Cuevas-Navarro Emily G. Shuldiner Martha Vega Walid K. Chatila Jierui Xu Henry Walch Yuzhe Niu Dmitri A. Petrov Nikolaus Schultz Anatoly Urisman Charles M. Rudin Monte M. Winslow Pau Castel

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Key Points

RIT1 is identified as a driver of oncogenic transformation in lung adenocarcinoma, marking it as a distinct target for intervention.
Genetic analysis demonstrates that mutations in RIT1 significantly contribute to tumorigenesis, supporting its role in cancer progression.
The study employs gene analysis methods to explore the tumorigenic mechanisms involving RIT1, highlighting its potential clinical relevance.
The findings suggest that targeting RIT1 could provide new avenues for treatment in patients with lung adenocarcinoma.

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Implication

Analysis reveals RIT1 drives oncogenic transformation in lung adenocarcinoma, indicating a potential therapeutic target.

Abstract

Analysis of tumors and genes involved in RIT1 tumorigenesis

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Cite This Study

Mozzarelli et al. (2025) studied this question.

synapsesocial.com/papers/68bb5f076d6d5674bcd02b72 https://doi.org/10.1158/0008-5472.30029662

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Data Figure S1 from RIT1 Drives Oncogenic Transformation and Is an Actionable Target in Lung Adenocarcinoma2025
2Supplementary Data Figure S3 from RIT1 Drives Oncogenic Transformation and Is an Actionable Target in Lung Adenocarcinoma2025
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4Supplementary Figure S1 from RIT1<sup>M90I</sup> Is a Driver of Lung Adenocarcinoma Tumorigenesis and Resistance to Targeted Therapy2025
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