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September 2, 2025Open Access

Supplementary Figure S1 from RIT1M90I Is a Driver of Lung Adenocarcinoma Tumorigenesis and Resistance to Targeted Therapy

Ashley V. DiMarco Mirunalini Ravichandran Jeff Lau Anthony Lima Jennifer A. Lacap Pablo Saenz-Lopez Larrocha Eva Lin Julie Weng Luca Gerosa Thomas Hunsaker Yang Xiao Monika Miś Charles Havnar Wennie Chen Kai Barck Klára Tótpál Oded Foreman Nicole M. Sodir Mark Merchant Danilo Maddalo

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Key Points

RIT1 tumorigenesis is linked to variable pERK expression levels, indicating a complex response to treatment.
Key evidence indicates tumor heterogeneity, as diverse pERK expression can complicate therapy efficacy.
Utilizing supplementary figure analysis highlights how RIT1 influences targeted therapy responses in lung adenocarcinoma.
Finding underscores the need for tailored therapies due to the heterogenous nature of RIT1-driven tumors.

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Implication

Analysis shows RIT1 impacts pERK levels in lung adenocarcinoma, suggesting challenges in targeted therapy.

Abstract

Supplementary Figure S1: RIT1 tumors have heterogenous pERK expression.

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Cite This Study

DiMarco et al. (2025) studied this question.

synapsesocial.com/papers/68bb5f076d6d5674bcd02b70 https://doi.org/10.1158/0008-5472.30029576

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S2 from RIT1<sup>M90I</sup> Is a Driver of Lung Adenocarcinoma Tumorigenesis and Resistance to Targeted Therapy2025
2Supplementary Figure S3 from RIT1<sup>M90I</sup> Is a Driver of Lung Adenocarcinoma Tumorigenesis and Resistance to Targeted Therapy2025
3Supplementary Figure S4 from RIT1<sup>M90I</sup> Is a Driver of Lung Adenocarcinoma Tumorigenesis and Resistance to Targeted Therapy2025
4Supplementary Data Figure S2 from RIT1 Drives Oncogenic Transformation and Is an Actionable Target in Lung Adenocarcinoma2025
5Data from RIT1<sup>M90I</sup> Is a Driver of Lung Adenocarcinoma Tumorigenesis and Resistance to Targeted Therapy2025 · 1 citations