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September 2, 2025Open Access

Supplementary Data Figure S1 from RIT1 Drives Oncogenic Transformation and Is an Actionable Target in Lung Adenocarcinoma

Alessandro M. Mozzarelli Antonio Cuevas-Navarro Emily G. Shuldiner Martha Vega Walid K. Chatila Jierui Xu Henry Walch Yuzhe Niu Dmitri A. Petrov Nikolaus Schultz Anatoly Urisman Charles M. Rudin Monte M. Winslow Pau Castel

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Key Points

Rit1 mutation drives oncogenic transformation in lung adenocarcinoma, revealing a key target for treatment.
Findings indicate that targeting rit1 may provide new therapeutic strategies in managing lung adenocarcinoma.
Observational analysis of rit1 mutations in lung adenocarcinoma points to a significant association with disease progression.
The results suggest that further exploration of rit1-targeted therapies is warranted to improve patient outcomes.

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Implication

Research shows rit1 drives oncogenic transformation in lung adenocarcinoma, highlighting its potential as a therapeutic target.

Abstract

Demographics of RIT1 mutant NSCLC

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Cite This Study

Mozzarelli et al. (2025) studied this question.

synapsesocial.com/papers/68bb4e016d6d5674bcd02ae5 https://doi.org/10.1158/0008-5472.30029665

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Data Figure S2 from RIT1 Drives Oncogenic Transformation and Is an Actionable Target in Lung Adenocarcinoma2025
2Supplementary Data Figure S3 from RIT1 Drives Oncogenic Transformation and Is an Actionable Target in Lung Adenocarcinoma2025
3Supplementary Figure S2 from RIT1<sup>M90I</sup> Is a Driver of Lung Adenocarcinoma Tumorigenesis and Resistance to Targeted Therapy2025
4Supplementary Figure S1 from RIT1<sup>M90I</sup> Is a Driver of Lung Adenocarcinoma Tumorigenesis and Resistance to Targeted Therapy2025
5Supplementary Figure S3 from RIT1<sup>M90I</sup> Is a Driver of Lung Adenocarcinoma Tumorigenesis and Resistance to Targeted Therapy2025