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September 5, 2025MedicineOpen Access

Causal relationship between circulating immune cells and diabetic nephropathy: A Mendelian randomization study

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Authors

TWTao WangCHChun HuangYMYuxia Mo

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Overview

Mendelian randomization establishes a significant association between eosinophil counts and diabetic nephropathy, suggesting new diagnostic avenues.

Key Points

  • Increased eosinophil counts significantly raise the risk of diabetic nephropathy, with an odds ratio of 1.21.
  • Findings indicate that higher eosinophil levels may contribute to diabetic nephropathy progression towards end-stage renal disease.
  • The study utilized Mendelian randomization to evaluate causal relationships using genome-wide association study data.
  • Absence of causal links between lymphocyte subtypes and diabetic nephropathy points to the need for larger-scale studies.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68bb5f7a6d6d5674bcd03d00https://doi.org/10.1097/md.0000000000043182
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