Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 30, 2025Journal of Diabetes InvestigationOpen Access

Causal association between circulating leukocyte characteristics and diabetic retinopathy based on two‐sample Mendelian randomization

View Full Paper
Ask AI
Bookmark
Share

Authors

YWYan WangYGYunxian GaoZWZhiqiang Wang

Discussion

Loading...

Member takes

Overview

Mendelian randomization reveals increased leukocyte counts link to diabetic retinopathy, suggesting further exploration of their physiological role.

Key Points

  • Leukocyte counts are causally associated with diabetic retinopathy, with lymphocytes showing a potential protective effect.
  • IVW analysis indicated a 7% reduced risk of diabetic retinopathy with higher lymphocyte counts, supporting further investigation.
  • Utilizing Mendelian randomization, the study’s approach incorporated robust sensitivity analyses including weighted median and MR-PRESSO testing.
  • These findings highlight the need for focused research on the physiological role of leukocytes in managing diabetic retinopathy.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/692b9da91d383f2b2a37a4e3https://doi.org/10.1111/jdi.70196
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The causal relationship between immune cells and diabetic retinopathy: a Mendelian randomization study2024
  2. 2Causal relationship between circulating immune cells and diabetic nephropathy: A Mendelian randomization study2025
  3. 3Causal influence of immune factors on the risk of diabetic retinopathy: a mendelian randomization study2024
  4. 4Causal association between blood leukocyte counts and vascular dementia: a two-sample bidirectional Mendelian randomization study2024 · 5 citations
  5. 5Causal Relationship Between Circulating Leukocyte Characteristics and Immune Cell Traits With Multiple Sclerosis Risk: A Two-Sample Bidirectional Mendelian Randomisation Study2026