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July 15, 2026Cellular and Molecular NeurobiologyOpen Access

Causal Relationship Between Circulating Leukocyte Characteristics and Immune Cell Traits With Multiple Sclerosis Risk: A Two-Sample Bidirectional Mendelian Randomisation Study

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Authors

JYJia-Jia YunYLYa-Lei LiJQJingman Qiu

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Overview

Randomized trial finds increased leukocyte counts elevate multiple sclerosis risk, suggesting immune traits may reduce risk.

Key Points

  • The study aims to investigate the causal relationships between leukocyte characteristics, immune cell traits, and multiple sclerosis risk using Mendelian randomisation.
  • Utilized a two-sample bidirectional Mendelian randomisation approach with summary-level data.
  • Analyzed data using inverse variance weighted, MR-Egger methods, and other statistical techniques.
  • Adjusted for multiple comparisons with false discovery rate (FDR) methods.
  • Increased white blood cell count was associated with a higher risk of MS (OR = 1.16, 95% CI = 1.05–1.29, P = 0.004).
  • Increased lymphocyte count also elevated MS risk (OR = 1.18, 95% CI = 1.06–1.31, P = 0.003).
  • Certain immune cell traits, like CD25hi CD45RA-CD4, were linked to reduced MS risk (OR = 0.87, 95% CI = 0.808–0.942, P = 0.0005).

Cite This Study

Yun et al. (2026) studied this question.

synapsesocial.com/papers/6a57242188b21df875480a6bhttps://doi.org/10.1007/s10571-026-01777-9
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