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September 10, 2025Frontiers in Veterinary ScienceOpen Access

Astaxanthin alleviates oxidative stress and skeletal muscle damage by promoting mitochondrial biogenesis

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Authors

CLChengmu LiYYYuting YanKWKai Wang

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Overview

This research demonstrates how astaxanthin reduces oxidative stress and enhances mitochondrial biogenesis in skeletal muscle, suggesting its therapeutic role under metabolic stress.

Key Points

  • Astaxanthin significantly alleviates skeletal muscle damage by enhancing mitochondrial biogenesis and reducing oxidative stress.
  • Mice on a high-fat diet showed improved muscle function after astaxanthin treatment while body weight remained unchanged.
  • Assessment included histology, quantitative PCR, and biochemical assays to measure oxidative stress and muscle pathology.
  • Findings suggest astaxanthin could serve as a therapeutic agent for skeletal muscle protection during metabolic stress.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68c1824b9b7b07f3a060ea46https://doi.org/10.3389/fvets.2025.1577408
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Astaxanthin improves skeletal muscle regeneration in CTX-induced injury of HFD-fed obese mice via mitochondrial biogenesis2024 · 2 citations
  2. 2Astaxanthin Ameliorates Skeletal Muscle Atrophy in Mice With Cancer Cachexia2024 · 7 citations
  3. 3Effects of Astaxanthin on Chronic Exercise Fatigue2025
  4. 4Taking Astaxanthin Supplementation Attenuates MDA and HMGB1 Following Eccentric Exercise: A Randomized Controlled Trial in Recreationally Active Students2025
  5. 5Anti-Inflammatory and Antioxidant Action of Astaxanthin and Its Applications in the Treatment of Muscle Health: A Systematic Review2025