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September 29, 2025Physical Education Theory and MethodologyOpen Access

Taking Astaxanthin Supplementation Attenuates MDA and HMGB1 Following Eccentric Exercise: A Randomized Controlled Trial in Recreationally Active Students

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Authors

RIRoy Januardi IrawanRDRatna Candra DewiABAnanda Perwira Bakti

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Overview

Randomized controlled trial found astaxanthin supplementation lowers MDA and HMGB1 in recreationally active students, suggesting potential anti-inflammatory benefits.

Key Points

  • Astaxanthin supplementation reduced elevations of oxidative stress marker MDA and inflammatory marker HMGB1 post-exercise.
  • The AST group showed a 151% increase in MDA versus 187% in the placebo group, indicating better management of oxidative stress.
  • Significantly greater reductions in MDA and HMGB1 were noted in the AST group at 24 hours post-exercise compared to placebo.
  • These results imply astaxanthin could be an effective nutritional strategy for athletes experiencing oxidative stress.

Cite This Study

Irawan et al. (2025) studied this question.

synapsesocial.com/papers/68da58d8c1728099cfd10fb4https://doi.org/10.17309/tmfv.2025.5.20
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of Antioxidant Supplementation on Exercise-Induced Cardiac Troponin Release in Cyclists: A Randomized Trial2013 · 37 citations
  2. 2The Effects of Astaxanthin Supplementation on Exercise Recovery Biomarkers and Exercise Performance: A Systematic Review and Meta-Analysis2026 · 2 citations
  3. 3Effects of Astaxanthin on Chronic Exercise Fatigue2025
  4. 4THE EFFECT OF RESISTANCE TRAINING AND ANTIOXIDANT SUPPLEMENTATION WITH ASTAXANTHIN ON PLASMA MALONDIALDEHYDE (MDA) LEVELS IN ADULTS2025
  5. 5The effect of astaxanthin supplementation on inflammatory markers, lipid profile, and anthropometric indices in patients with heart failure: a randomized controlled trial2026