Figure S12 from PPARδ Orchestrates a Prometastatic Metabolic Response to Microenvironmental Cues in Pancreatic Cancer

Beatriz Parejo-Alonso; David Barneda; Sara Maria David Trabulo; Sarah Courtois; Sara Compte-Sancerni; Jelena Zurkovic; Laura Ruíz-Cañas; Quan Zheng; Jiajia Tang; Matthias M. Gaida; Ulf Schmitz; Pilar Irún; Laure Penin-Peyta; Shanthini Mary Crusz; Petra Jagušt; Pilar Espiau-Romera; Alba Royo-García; Andrés Gordo-Ortiz; Mariia Yuneva; Meng‐Lay Lin; Shenghui Huang; Ming-Hsin Yang; Ángel Lanas; Bruno Sáinz; Christoph Thiele; Christopher Heeschen; Patricia Sancho

doi:10.1158/0008-5472.30029468

Key Points

Downregulation of MYC reverses the prometastatic phenotype, enhancing treatment potential.
Experiments show that blocking PPARδ can alter metabolic responses in pancreatic cancer cells.
Analysis focuses on the influence of microenvironmental cues in cancer cell metabolism.
Findings may help identify new strategies for targeting pancreatic cancer metastasis.

Implication

Observational analysis reveals that downregulating MYC reverses the prometastatic phenotype induced by etomoxir in pancreatic cancer, indicating potential therapeutic strategies.

Abstract

MYC downregulation reverses the prometastatic phenotype induced by etomoxir and MCM

Discussion

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Cite This Study

Parejo-Alonso et al. (2025) studied this question.

synapsesocial.com/papers/68c183f09b7b07f3a060f731 https://doi.org/10.1158/0008-5472.30029468

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Figure S12 from PPARδ Orchestrates a Prometastatic Metabolic Response to Microenvironmental Cues in Pancreatic Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure S12 from PPARδ Orchestrates a Prometastatic Metabolic Response to Microenvironmental Cues in Pancreatic Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

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