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September 3, 2025Open Access

Supplementary Figure S6 from HuR-Regulated Extracellular Vesicles Promote Endothelial Cell Remodeling in Pancreatic Cancer

Jennifer M. Finan Yifei Guo Alexandra Q. Bartlett Kevin Hawthorne Matthew Reyer Margaret Haerr Olayinka Lamikanra Hen Halamish Valerie Calvert Canping Chen Zheng Xia Emanuel F. Petricoin Rosalie C. Sears Katelyn T. Byrne Jonathan R. Brody

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Key Points

Extracellular vesicles promote endothelial cell remodeling in pancreatic cancer, enhancing tumor dynamics.
Results indicate that EVs injected into mice are effectively taken up by cells in PDAC tumors, impacting their behavior.
This analysis focuses on the role of extracellular vesicles in modifying endothelial cell responses in the context of pancreatic cancer.
Findings support the importance of HuR-regulated extracellular vesicles in cancer biology and potential therapeutic avenues.

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Implication

Observational analysis highlights how extracellular vesicles impact endothelial cells in PDAC, suggesting a role in tumor dynamics.

Abstract

EV injected into mice are imported by cells in PDAC tumors.

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Cite This Study

Finan et al. (2025) studied this question.

synapsesocial.com/papers/68c183f09b7b07f3a060fa70 https://doi.org/10.1158/2767-9764.30038860

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S3 from HuR-Regulated Extracellular Vesicles Promote Endothelial Cell Remodeling in Pancreatic Cancer2025
2Supplementary Figure S2 from HuR-Regulated Extracellular Vesicles Promote Endothelial Cell Remodeling in Pancreatic Cancer2025
3Supplementary Figure S4 from HuR-Regulated Extracellular Vesicles Promote Endothelial Cell Remodeling in Pancreatic Cancer2025
4Supplementary Figure S1 from HuR-Regulated Extracellular Vesicles Promote Endothelial Cell Remodeling in Pancreatic Cancer2025
5Supplementary Data 1 from HuR-Regulated Extracellular Vesicles Promote Endothelial Cell Remodeling in Pancreatic Cancer2025