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September 10, 2025Advanced ScienceOpen Access

OSNRT1.1B‐OSCNGC14/16‐CA²⁺‐OSNLP3 Pathway: Phosphorylation‐Mediated Maintenance of Nitrogen Homeostasis

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Nitrate signaling significantly enhances nitrogen homeostasis by activating the OsNLP3 pathway in rice.
Experimental findings reveal that disrupting OsCNGC14 or OsCNGC16 interrupts Ca 2 + signaling, reducing primary nitrate response.
The study introduces a new signaling pathway that combines nitrate uptake with long-term nitrogen utilization strategies.
Phosphorylation of OsNLP3 accelerates gene activation related to nitrate response, indicating dual regulatory functions.

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Analysis identifies a novel signaling pathway regulating nitrate uptake in rice, involving Ca 2 + signaling and nitrogen homeostasis.

Wang et al. (2025) studied this question.

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