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Exploring the design space for Triton X‐100 substitutes in viral inactivation applications

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Systematic exploration provides minimum effective concentrations for alternatives, suggesting improved viral inactivation efficacy.

The study shows effective viral inactivation, achieving log 10 reductions greater than 4 against various viruses.
Identification of substitutes like TXR-1/VIS/13-S9 demonstrated broad-spectrum efficacy against Bovine viral diarrhea virus and more.
Systematic research established minimum effective concentrations and material-dependent inactivation dynamics for substitutes.
Process optimization revealed extending exposure time enhances effectiveness of eco-friendly detergents, ensuring compliance with standards.

Du et al. (2025) studied this question.

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