What question did this study set out to answer?

To evaluate the antiviral efficacy of eco-friendly glucosides and amine oxides as sustainable replacements for Triton X-100 in biomanufacturing viral inactivation processes.

April 1, 2025Biotechnology Journal

Impact of Eco‐Friendly Surfactant Structure and Class on Enveloped Virus Inactivation

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Authors

VSVaishali SharmaMichigan Technological University LMLynn ManchesterMichigan Technological University MHMelissa HolsteinBristol-Myers Squibb (Germany)

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Implication

Experimental study demonstrates that eco-friendly glucoside surfactants effectively inactivate enveloped viruses, indicating viable sustainable alternatives to Triton X-100.

Key Points

To evaluate the antiviral efficacy of eco-friendly glucosides and amine oxides as sustainable replacements for Triton X-100 in biomanufacturing viral inactivation processes.
Evaluated the antiviral efficacy of eco-friendly surfactants against enveloped viruses, specifically herpesviruses (SuHV and HSV) and a retrovirus (XMuLV), compared to Triton X-100.
Assessed virus log reduction values across multiple concentrations (0.5x, 1x, and 2x critical micelle concentration [CMC]) and under high ionic strength conditions (2 M salt).
Tested surfactants demonstrated equivalent or superior viral inactivation compared to Triton X-100, with longer alkyl chain surfactants achieving maximum log reduction values at 1x CMC against XMuLV whereas Triton X-100 required 2x CMC.
Surfactants with bulky headgroups such as LAPAO exhibited lower antiviral efficacy against retroviruses, and high ionic strength (2 M salt) reduced herpesvirus inactivation for both Triton X-100 and TDAO.
The glucoside n-nonyl-β-D-glucoside (NG) emerged as the most robust candidate, maintaining effective virus inactivation across all tested environmental and concentration variables.

Cite This Study

Sharma et al. (2025) studied this question.

synapsesocial.com/papers/6aa2c2eb6401f02f7be5702d https://doi.org/10.1002/biot.70023

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Implication

Experimental study demonstrates that eco-friendly glucoside surfactants effectively inactivate enveloped viruses, indicating viable sustainable alternatives to Triton X-100.

Impact of Eco‐Friendly Surfactant Structure and Class on Enveloped Virus Inactivation

Discussion

Member takes

Implication

Key Points

Cite This Study

Impact of Eco‐Friendly Surfactant Structure and Class on Enveloped Virus Inactivation

Discussion

Member takes

Implication

Key Points

Cite This Study

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