The Relationship Between Motoric Cognitive Risk Syndrome and All-Cause Mortality in Older People: findings from CHARLS 2011–2023

Abstract Background: This study aims to investigate the relationship between motoric cognitive risk syndrome (MCR) and all-cause mortality in older people in China, providing a reference for early intervention in MCR among elderly populations in developing countries. Methods: Data were drawn from the China Health and Retirement Longitudinal Study (CHARLS) conducted from 2011 to 2023, involving 6,304 participants aged 60 and above. A Cox proportional hazards model was used to evaluate the impact of MCR on all-cause mortality. Results: The study found an association between MCR and all-cause mortality in older people. Among the participants, 15.5% (934/6304) died during the follow-up period, with 20.9% (256/1227) from the MCR group and 13.4% (678/5077) from the non-MCR group. The Cox model indicated that MCR was associated with a higher risk of all-cause mortality (HR=1.54, 95% CI: 1.34-1.78). This association remained significant after adjusting for all confounders (HR=1.46, 95% CI: 1.27-1.70). Conclusion: This study confirms that MCR is associated with an increased risk of all-cause mortality in older people.