Supplementary Figure S2 from Vascular Normalization Augments the Antitumor Efficacy of Combined HDAC Inhibitor with Immunotherapy in Solid Tumors

Min Wang; Yanxing Chen; Lin Tian; Chenyi Wu; Jiaying Chen; Jiajia Hu; Runjie Huang; Yingnan Wang; Jinling Zhang; Xiaojun Ouyang; Liqin Wang; Ying Jin; Qi Zhao; Feng Wang; Rui‐Hua Xu

doi:10.1158/2159-8290.30050808

September 4, 2025Open Access

Supplementary Figure S2 from Vascular Normalization Augments the Antitumor Efficacy of Combined HDAC Inhibitor with Immunotherapy in Solid Tumors

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Key Points

Vascular normalization enhances the antitumor efficacy of combined therapy.
The HDAC inhibitor reduces infiltration of CD8+ T cells, impacting treatment response.
The approach potentially improves outcomes in solid tumor settings with immunotherapy.
Understanding these interactions may lead to better therapeutic strategies for cancer.

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Implication

Findings reveal combined HDAC inhibitor and immunotherapy improves antitumor efficacy in solid tumors, implying vascular normalization may play a significant role.

Abstract

HDAC inhibitor hinders the infiltration of CD8+ T cells

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Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68c18c089b7b07f3a0614872 https://doi.org/10.1158/2159-8290.30050808

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Supplementary Figure S2 from Vascular Normalization Augments the Antitumor Efficacy of Combined HDAC Inhibitor with Immunotherapy in Solid Tumors

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S2 from Vascular Normalization Augments the Antitumor Efficacy of Combined HDAC Inhibitor with Immunotherapy in Solid Tumors

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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