Supplementary Figure S6 from Vascular Normalization Augments the Antitumor Efficacy of Combined HDAC Inhibitor with Immunotherapy in Solid Tumors

Min Wang; Yanxing Chen; Lin Tian; Chenyi Wu; Jiaying Chen; Jiajia Hu; Runjie Huang; Yingnan Wang; Jinling Zhang; Xiaojun Ouyang; Liqin Wang; Ying Jin; Qi Zhao; Feng Wang; Rui‐Hua Xu

doi:10.1158/2159-8290.30050796

September 4, 2025Open Access

Supplementary Figure S6 from Vascular Normalization Augments the Antitumor Efficacy of Combined HDAC Inhibitor with Immunotherapy in Solid Tumors

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Key Points

Vascular normalization boosts antitumor effects in patients receiving combined therapies for solid tumors.
Key evidence shows that anti-angiogenesis therapy significantly enhances CD8+ T cell infiltration.
Analysis of treatment outcomes from combined HDAC inhibitor and immunotherapy highlights increased efficacy.
Previous findings show that vascular normalization may enable more effective immunotherapy in solid tumors.

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Implication

Observational analysis reveals that vascular normalization boosts CD8+ T cell infiltration in solid tumors, suggesting improved combined treatment outcomes.

Abstract

Anti-angiogenesis therapy promotes the infiltration of CD8+ T cells

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Wang et al. (2025) studied this question.

synapsesocial.com/papers/68c18c089b7b07f3a0614909 https://doi.org/10.1158/2159-8290.30050796

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Supplementary Figure S6 from Vascular Normalization Augments the Antitumor Efficacy of Combined HDAC Inhibitor with Immunotherapy in Solid Tumors

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S6 from Vascular Normalization Augments the Antitumor Efficacy of Combined HDAC Inhibitor with Immunotherapy in Solid Tumors

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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