Supplementary Figure S9 from Vascular Normalization Augments the Antitumor Efficacy of Combined HDAC Inhibitor with Immunotherapy in Solid Tumors

Min Wang; Yanxing Chen; Lin Tian; Chenyi Wu; Jiaying Chen; Jiajia Hu; Runjie Huang; Yingnan Wang; Jinling Zhang; Xiaojun Ouyang; Liqin Wang; Ying Jin; Qi Zhao; Feng Wang; Rui‐Hua Xu

doi:10.1158/2159-8290.30050787

September 4, 2025Open Access

Supplementary Figure S9 from Vascular Normalization Augments the Antitumor Efficacy of Combined HDAC Inhibitor with Immunotherapy in Solid Tumors

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Key Points

Vascular normalization enhances the efficacy of treatment combinations, improving outcomes in solid tumors.
Treatment with HDAC inhibitors and immunotherapy showed a reduction in toxicity, attributed to improved vascular normalization.
Combination therapy involving anti-angiogenesis and HDAC inhibitors indicates promising outcomes for solid tumor management.
The findings point to the potential benefits of optimizing vascular conditions to improve cancer therapy.

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Implication

Observational analysis reveals improved efficacy of HDAC inhibitors with immunotherapy in solid tumors, suggesting vascular normalization may reduce toxicity.

Abstract

The toxicity of Combined HDAC inhibitor with anti-angiogenesis therapy

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Wang et al. (2025) studied this question.

synapsesocial.com/papers/68c18c089b7b07f3a06148b9 https://doi.org/10.1158/2159-8290.30050787

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Supplementary Figure S9 from Vascular Normalization Augments the Antitumor Efficacy of Combined HDAC Inhibitor with Immunotherapy in Solid Tumors

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S9 from Vascular Normalization Augments the Antitumor Efficacy of Combined HDAC Inhibitor with Immunotherapy in Solid Tumors

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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